![]() ![]() General Population risk (genotype unknown) Sometimes celiac disease is triggered, or becomes active for the first time, after surgery, viral infection or severe emotional stress.Įstimated Celiac Risk from Associated HLA Genotypes 6,7 4 Other high-risk groups who are likely to have these HLA alleles include people with autoimmune thyroiditis, rheumatoid arthritis, and IgA deficiency as well as individuals with symptoms of unexplained iron deficiency anemia or premature-onset osteoporosis. These HLA alleles are also found in 48-65% of first-degree relatives of people with CD and in up to 73% of people with insulin-dependent diabetes (type I diabetes) increasing these individual's risk of developing CD. The HLA-DQ2 allele has been found in about 95% of celiac cases, and HLA-DQ8 has been identified in nearly all 5% of the remaining cases. The chart below gives the CD risk associated with the allele variants identified by this test. This genetic predisposition to develop CD is linked to human leukocyte antigen (HLA) class II alleles, in the HLA-DQ region of chromosome 6. ![]() 1,2 Failure to identify CD due to its variable non-specific symptoms and varying age of onset may result in in life long complications as well as secondary autoimmune disorders. Although it is estimated that 1 out of 100 people are affected, fewer than 5% of those affected are actually diagnosed. DQ2 genotyping (DQA1*0501, DQA1*0505 and DQB1*0201/*0202)Ĭeliac disease (CD) is caused by an immune response to gluten (a protein found in cereal grains) in genetically predisposed people.This test provides complete genotyping of your DQA and DQB HLA protein chains and contains the following information: ![]()
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